Study identifies a new driver and therapeutic vulnerability of bone metastasis
One of the most common sites for cancer to metastasize is the bone. Unfortunately, patients with bone metastases have a poor prognosis and most treatments are focused on palliative care, highlighting a need for better therapeutic strategies. Because metastatic cells are known to reprogram metabolic states to adapt to their new environments, Li Ma, Ph.D., and colleagues examined the role of lipid metabolism – the breakdown and creation...
Study uncovers epigenetic driver of bone metastasis in advanced prostate cancer
Nearly 80% of men with advanced prostate cancer develop bone metastases, leading to bone pain, fractures and a poor prognosis. Using laboratory...
Antibody treatment is safe for elderly patients with relapsed/refractory multiple myeloma
Treatment with teclistamab, a bispecific antibody, was recently approved for patients with relapsed/refractory multiple myeloma (RRMM) based...
Biomarker-guided combination therapy targets subtype of advanced prostate cancer
Castration-resistant prostate cancer (CRPC) remains one of the most lethal and treatment-resistant forms of prostate cancer, highlighting a need to identify reliable biomarkers to predict therapy response. Researchers led by Feiyu Chen, Ph.D., and Di Zhao, Ph.D., used genetic models and multi-omics approaches to identify a key mechanism driving hormone therapy resistance in a specific prostate cancer subtype. They also developed...
Sickle cell disease changes DNA structure of cells to suppress immunity
Sickle cell disease changes DNA structure of cells to suppress immunity
Patients with sickle cell disease, an inherited disorder that...
Mapping changes in lung precancer reveals TIM-3 as potential intervention target
Lung cancer is often diagnosed at late stages, making treatment challenging. To understand its early development, researchers led...
Self-advocacy may lead to less pain in older breast cancer survivors
Many older female breast cancer survivors experience persistent pain, but they are unsure how to gauge pain intensity and often have anxiety...
Novel combination provides more effective treatment option for mantle cell lymphoma
The latest treatment for mantle cell lymphoma (MCL) – an aggressive and incurable B-cell lymphoma – includes Bruton tyrosine kinase (BTK)...
Activating leukemia stem cells makes chemotherapy more effective in AML
Acute myeloid leukemia (AML) is a hard-to-treat cancer in which certain leukemia stem/progenitor cells (LSPCs) hide in the bone marrow...
Study identifies potential biomarker for treatment response in glioblastoma
Glioblastoma, the most common type of central nervous system tumor, is generally resistant to immune checkpoint blockade, highlighting a need...